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Diabetes increases the mortality of patients with COVID-19: a meta-analysis

Zeng-Hong Wu1, Yun Tang2, Qing Cheng3

  • 1Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Acta Diabetologica
|June 26, 2020
PubMed

Insights

Diabetes significantly increases the mortality risk for patients diagnosed with COVID-19. This meta-analysis confirms a strong association between diabetes and adverse outcomes in coronavirus disease 2019 patients.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents significant risks, with pre-existing conditions like diabetes being major complications.
  • Understanding the impact of diabetes on COVID-19 patient outcomes is crucial for effective clinical management.

Purpose of the Study:

  • To conduct a meta-analysis investigating the relationship between diabetes and mortality in COVID-19 patients.
  • To assess if individuals with diabetes face a higher risk of adverse clinical outcomes when infected with SARS-CoV-2.
  • To evaluate the overall reliability of the existing evidence.

Main Methods:

  • Systematic literature review and meta-analysis.
  • Pooled analysis of data to determine the odds ratio (OR) for mortality in diabetic COVID-19 patients.
  • Sensitivity analysis to confirm the robustness of the findings.

Main Results:

  • A significant association was found between diabetes and increased COVID-19 mortality, with a pooled OR of 1.75 (95% CI 1.31-2.36, P=0.0002).
  • The fixed effects model was used due to the absence of heterogeneity among the included studies.
  • Sensitivity analyses confirmed the stability of the results.

Conclusions:

  • Diabetes is a significant risk factor that increases mortality in patients with COVID-19.
  • The findings suggest dysregulation of blood glucose metabolism in COVID-19 patients with diabetes.
  • This meta-analysis provides a graded assessment of evidence reliability for future research on diabetes and COVID-19.
Abstract

Keywords:
COVID-19DiabetesMeta-analysisSARS-CoV-2

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