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Patients have varied expectations and experiences with psychiatric pharmacogenetic (PGx) testing. The perceived value of PGx testing in mental health care depends on test results and cost.

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Area of Science:

  • Psychiatric pharmacogenetics
  • Clinical utility of PGx testing
  • Patient-centered outcomes

Background:

  • Growing interest in pharmacogenetic (PGx) testing in psychiatric medicine.
  • Mixed views on the clinical utility of PGx testing.
  • Increasing utilization of PGx testing by providers for patients with mental health disorders.

Purpose of the Study:

  • To assess genotyped patients' perspectives and experiences with psychiatric PGx testing.
  • To understand patient-reported outcomes of PGx testing in mental health care.

Main Methods:

  • Individual semi-structured interviews with patients diagnosed with depression who underwent PGx testing.
  • Audio-recorded interviews were transcribed and analyzed using inductive and deductive thematic analysis.

Main Results:

  • Twenty Caucasian patients (60% female, mean age 39) were interviewed.
  • Most PGx tests were provider-initiated due to treatment resistance or medication intolerances.
  • Patient expectations ranged from hopeful to skeptical; experiences varied from optimistic to disappointed, influenced by test results and cost.

Conclusions:

  • Genotyped patients reported mixed perspectives, expectations, and experiences with psychiatric PGx testing.
  • The perceived value of PGx testing is significantly influenced by test outcomes and associated costs.