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Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease
Bei Gao1, Atoosa Emami1, Shilpa Nath1
1Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Abstract:
As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, β-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.
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