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The Analysis for Anemia Increasing Fracture Risk
Yirong Teng1, Zhaowei Teng1, Shuanglan Xu2
1The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, China (mainland).
Summary
Anemia significantly increases fracture risk in the elderly, including hip and spine fractures. This finding highlights anemia as a potential predictor for fractures in older populations.
Area of Science:
- Gerontology
- Hematology
- Epidemiology
Background:
- Fractures pose a significant global health challenge for the elderly.
- Anemia is a prevalent health issue in older adults.
Purpose of the Study:
- To systematically review and meta-analyze the association between anemia and fracture incidence in the elderly.
Main Methods:
- Systematic review and meta-analysis adhering to PICOS guidelines.
- Database searches conducted from inception to May 2020.
- Random-effects model used for significant heterogeneity; subgroup analyses by sex, study design, and region.
Main Results:
- Anemia significantly elevates overall fracture risk (RR=1.26).
- Increased risk observed for hip (RR=1.44), spine (RR=1.15), and non-spine fractures (RR=1.42).
- Higher risk in males (1.51-fold) vs. females (1.09-fold); stronger association in Asian populations.
Conclusions:
- Anemia is a significant predictor of increased fracture risk in the elderly.
- Findings underscore the importance of addressing anemia in geriatric fracture prevention strategies.
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