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Alpha-terpineol complexed with beta-cyclodextrin reduces damages caused by periodontitis in rats
Any Carolina Cardoso Guimarães Vasconcelos1,2, Daniel Fernando Pereira Vasconcelos3, Felipe Rodolfo Pereira da Silva3
1Medicinal Plants Research Center (NPPM), Federal University of hPiaui, Teresina, Brazil.
Journal of Periodontal Research
|June 26, 2020
Summary
Alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) improved oral and blood markers in periodontitis-affected rats. This treatment also ameliorated hepatic steatosis and reduced lipid accumulation in liver cells.
Area of Science:
- Periodontology
- Pharmacology
- Hepatology
Background:
- Periodontitis is an inflammatory condition affecting oral tissues.
- Periodontitis can lead to systemic complications, including hepatic alterations.
- Alpha-terpineol (αTPN) is a natural compound with potential therapeutic properties.
Purpose of the Study:
- To evaluate the efficacy of alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD).
- To assess the impact of αTPN-βCD treatment on oral health, blood biomarkers, and liver function in a rat model of periodontitis.
Main Methods:
- Periodontitis was induced in female rats using ligatures around the first lower molars.
- Rats received daily intraperitoneal injections of vehicle solution, or αTPN-βCD at 5 mg/kg or 25 mg/kg for 20 days.
- Oral parameters, blood biomarkers, and liver histopathology (light and transmission electron microscopy) were analyzed.
Main Results:
- αTPN-βCD treatment significantly improved oral parameters and blood biomarkers compared to periodontitis-only group.
- Hepatotoxicity markers, including steatosis score, were significantly reduced by αTPN-βCD.
- Histopathological analysis showed decreased lipid droplets and foamy cytoplasm in hepatocytes of treated rats.
Conclusions:
- αTPN-βCD demonstrates significant therapeutic potential in managing experimental periodontitis.
- The treatment effectively improved systemic markers and ameliorated periodontitis-induced liver damage.
- αTPN-βCD represents a promising therapeutic agent for periodontitis and its associated hepatic complications.
