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Related Experiment Videos

[Multiple brain infarcts in zoster infection].

A Karenberg1, H J Schädlich, H Karbe

  • 1Universitäts-Nervenklinik, Universität zu Köln.

Der Nervenarzt
|January 1, 1988
PubMed
Summary

Cerebral zoster angiitis, a rare condition, was diagnosed in a 14-year-old female presenting with multiple cerebral infarctions. Intrathecal synthesis of zoster antibodies confirmed the diagnosis, highlighting challenges in managing inflammatory vascular lesions.

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Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Cerebral zoster angiitis is a rare inflammatory vascular condition affecting the brain.
  • Early diagnosis and treatment are crucial for managing inflammatory vascular lesions.

Observation:

  • A 14-year-old female patient presented with clinical symptoms, cerebrospinal fluid (CSF), computed tomography (CT), and positron emission tomography (PET) findings.
  • CT and PET scans revealed multiple cerebral infarctions.
  • CSF examinations indicated inflammatory changes.

Findings:

  • Enzyme-linked immunosorbent assay (ELISA) detected intrathecal synthesis of zoster antibodies.
  • Serum and CSF IgG concentrations were adjusted to identical levels for accurate antibody detection.

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  • The findings led to the diagnosis of cerebral zoster angiitis.

    • Implications:

    • This case highlights the diagnostic challenges associated with inflammatory vascular lesions of the brain.
    • Effective diagnostic and therapeutic strategies are essential for improving patient outcomes.
    • Understanding intrathecal antibody synthesis is key in diagnosing such conditions.