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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
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Fatal underhanded chronic enterovirus infection associated with anti-CD20 monotherapy for central nervous system

Léa Luciani1, Laetitia Ninove1, Christine Zandotti1

  • 1Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France; Laboratoire de microbiologie (Assistance Publique - Hôpitaux de Marseille; IHU Méditerranée Infection) Marseille, France.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 26, 2020
PubMed

Insights

A chronic coxsackievirus B4 infection led to fatal myocarditis in a woman with myelin oligodendrocyte glycoprotein antibody-associated disorder. The same virus caused initial meningitis and later, severe heart inflammation.

Area of Science:

  • Virology
  • Neurology
  • Cardiology

Background:

  • Myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD) is an autoimmune condition affecting the central nervous system.
  • Rituximab is an effective B-cell depleting therapy for MOGAD, often used as monotherapy.
  • Viral infections can sometimes trigger or exacerbate autoimmune conditions.
Keywords:
Enterovirusmultiple sclerosismyocarditisneuromyelitis optica spectrum disorderrituximab

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