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An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

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The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation

Chuanbin Shen1,2,3,4, Ming Liu5, Runjia Xu1

  • 1Key Laboratory of Bioactive Peptides, Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Blood
|June 26, 2020
PubMed
Summary

Researchers identified a novel 14-3-3ζ-c-Src-integrin-β3 complex in platelets. Targeting this complex with a KF7 peptide inhibits thrombosis without increasing bleeding risk, offering a new antithrombotic strategy.

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