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How I treat unexplained arterial thrombosis
1Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL; and.
Blood
|June 26, 2020
Summary
Hematologists can diagnose unexplained arterial thrombosis by systematically evaluating hypercoagulable disorders, vascular issues, and systemic diseases. This approach aids in selecting appropriate secondary prevention strategies like anticoagulation or antiplatelet therapy.
Area of Science:
- Hematology
- Vascular Medicine
- Diagnostic Medicine
Background:
- Arterial thrombotic events often stem from atherosclerosis or cardioembolism.
- Hematologists frequently encounter nonatherosclerotic, noncardioembolic arterial events, termed unexplained arterial thrombosis.
Observation:
- A systematic diagnostic approach is crucial for unexplained arterial thrombosis.
- This approach must consider hypercoagulable disorders, pro-thrombotic agents, vascular abnormalities, and systemic diseases like malignancy and autoimmune conditions.
Findings:
- The literature on hypercoagulable disorders in arterial thrombosis is reviewed.
- A practical approach to thrombophilia workup following unexplained arterial events is discussed.
Implications:
- Case studies illustrate the diagnostic schema and management of unexplained arterial thrombosis.
- Key management decisions involve choosing between anticoagulation and antiplatelet therapy for secondary prevention.
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