Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation and HLA-B27.

S Meri1, J Partanen, M Leirisalo-Repo

  • 1Department of Bacteriology and Immunology, University of Helsinki, Finland.

Annals of the Rheumatic Diseases
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GWAS of Second-Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Fine structure in the <math></math>  decay of <math></math> Hg and <math></math> Au.

The European physical journal. A, Hadrons and nuclei·2025
Same author

Varying outcomes of triple-negative breast cancer in different age groups-prognostic value of clinical features and proliferation.

Breast cancer research and treatment·2022
Same author

Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation.

Molecular human reproduction·2022
Same author

Tumor-infiltrating lymphocytes and CD8<sup>+</sup> T cells predict survival of triple-negative breast cancer.

Journal of cancer research and clinical oncology·2019
Same author

Genomic prediction of relapse in recipients of allogeneic haematopoietic stem cell transplantation.

Leukemia·2018
Same journal

Mapping inequalities in rheumatology care in Europe: the first edition of the EULAR RheumaFacts project.

Annals of the rheumatic diseases·2026
Same journal

Commentary on 'Assessing the performance of AI chatbots in answering patients common questions about low back pain'.

Annals of the rheumatic diseases·2026
Same journal

Response to Correspondence on 'Safety and immunogenicity of the recombinant zoster vaccine in patients with rheumatoid arthritis using abatacept: a pilot multicentre, double-blind, randomised controlled trial'.

Annals of the rheumatic diseases·2026
Same journal

Correspondence on 'Safety and immunogenicity of the recombinant zoster vaccine in patients with rheumatoid arthritis using abatacept: a pilot multicentre, double-blind, randomised controlled trial' by Hawkins et al.

Annals of the rheumatic diseases·2026
Same journal

Response to correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.

Annals of the rheumatic diseases·2026
Same journal

Correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.

Annals of the rheumatic diseases·2026
See all related articles

Individuals with the HLA-B27 gene show increased complement activation, a key immune response. This heightened response may play a role in developing HLA-B27 associated inflammatory diseases.

Area of Science:

  • Immunology
  • Genetics

Background:

  • The human leukocyte antigen B27 (HLA-B27) is strongly associated with several inflammatory diseases.
  • The complement system is a critical component of the innate immune system, involved in host defense and inflammation.

Purpose of the Study:

  • To investigate the efficiency of complement activation in individuals with and without the HLA-B27 gene.
  • To determine if HLA-B27 influences complement system responsiveness.

Main Methods:

  • Sera from HLA-B27 positive and negative subjects were analyzed for complement activation.
  • Complement activation was induced using zymosan and lipopolysaccharide (LPS) from Escherichia coli 0111:B4.
  • Levels of complement fragments C3a and C3d,g were measured.

Main Results:

Related Experiment Videos

  • Higher mean levels of the anaphylatoxin C3a were observed in HLA-B27 positive sera after zymosan activation.
  • Increased levels of the C3 breakdown fragment C3d,g were found in HLA-B27 positive sera following LPS treatment.
  • These differences persisted regardless of prior arthritis, complement phenotypes, or baseline complement levels.

Conclusions:

  • The study suggests an increased responsiveness of the complement system to activators in individuals carrying the HLA-B27 gene.
  • This heightened complement activation may contribute to the pathogenesis of HLA-B27 associated inflammatory diseases.