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HIPDM-SPECT in patients with medically intractable complex partial seizures. Ictal study
B I Lee1, O N Markand, H N Wellman
1Department of Neurology, Indiana University Medical Center, Indianapolis 46223.
Archives of Neurology
|April 1, 1988
Summary
Ictal HIPDM-SPECT effectively identifies epileptic foci in complex partial seizures by showing increased brain perfusion. This technique aids in localizing seizure origins, especially when combined with EEG data.
Area of Science:
- Neurology
- Nuclear Medicine
- Radiology
Background:
- Complex partial seizures (CPS) present diagnostic challenges.
- Accurate localization of epileptic foci is crucial for effective treatment.
Purpose of the Study:
- To evaluate the utility of ictal N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3,propanediamine -single photon emission computed tomography (HIPDM-SPECT) in localizing epileptic foci in patients with medically intractable CPS.
- To correlate HIPDM-SPECT findings with electroencephalography (EEG).
Main Methods:
- HIPDM-SPECT scans (interictal and ictal) were performed on 16 patients with medically intractable CPS.
- Regional cerebral perfusion (rCP) was analyzed.
- Ictal EEG was simultaneously recorded.
Main Results:
- Ictal HIPDM-SPECT localized epileptic foci in 13 of 14 patients with unilateral temporal foci.
- Increased rCP in epileptic foci confirmed seizure origins in 11 patients.
- Bitemporal foci showed complex bilateral perfusion patterns.
Conclusions:
- Ictal HIPDM-SPECT is a valuable tool for investigating and localizing epileptic foci in CPS.
- Combining ictal HIPDM-SPECT with ictal EEG enhances the precision of focus localization.