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Regulatory Roles of Circular RNAs in Coronary Artery Disease

Shuchen Zhang1, Wenjing Wang1, Xiaoguang Wu1

  • 1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P.R. China.

Molecular Therapy. Nucleic Acids
|June 26, 2020
PubMed

Insights

Circular RNAs (circRNAs) are emerging as key regulators in coronary artery disease (CAD). This review summarizes their roles in CAD pathogenesis, highlighting novel therapeutic targets for this widespread cardiac disorder.

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Noncoding RNA Research

Background:

  • Coronary artery disease (CAD) is a leading cause of global mortality, necessitating novel therapeutic strategies.
  • Current treatments for CAD exist, but there is a significant need for new molecular targets.
  • Circular RNAs (circRNAs) are a recently identified class of noncoding RNAs with regulatory functions.

Purpose of the Study:

  • To comprehensively review and summarize the pathological roles of circRNAs in CAD.
  • To consolidate current knowledge on circRNAs in the context of coronary atherosclerosis, myocardial infarction, ischemia/reperfusion injury, and ischemic heart failure.
  • To identify circRNAs as potential novel molecular therapeutic targets for CAD.

Main Methods:

  • Systematic review of published research linking circRNAs to CAD.
  • Analysis of studies detailing the regulatory mechanisms of circRNAs in cardiovascular disease.
  • Synthesis of findings on circRNAs in various CAD-related pathologies.

Main Results:

  • CircRNAs play significant roles in the pathogenesis of coronary atherosclerosis.
  • Specific circRNAs are implicated in the development and progression of myocardial infarction.
  • CircRNAs are involved in the molecular mechanisms underlying ischemia/reperfusion injury and ischemic heart failure.

Conclusions:

  • CircRNAs represent a critical regulatory layer in the development of CAD.
  • Understanding circRNA function offers promising avenues for novel therapeutic interventions in CAD.
  • Further research into circRNAs is warranted to fully exploit their potential in treating cardiovascular diseases.

Keywords:
circular RNAscoronary artery diseasepathogenesis

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