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Dermatologic management of oncotherapy side effects: A proposed algorithm
Marta Carlesimo1, Flavia Pigliacelli1, Andrea D'Arino1
1Department of Internal Medicine and Medical Specialties, UOC Dermatology, Sapienza University of Rome, Rome, Italy.
Abstract:
Since the introduction of the first chemotherapeutic regimens for the treatment of oncological disease, hundreds of drugs have been approved for cancer treatment and many more are under investigation. The development of newer drugs such as target therapies, immuno-oncotherapies, and hormonal therapies has increased in specificity with the development of smaller molecules and more selective targets. Cutaneous side effects are now well known for both standard chemotherapy and targeted therapies. The correct diagnosis and management of these effects are of vital importance both to optimize therapeutic success rates and to reduce the patient's suffering. In fact, the appearance of a cutaneous adverse event can be responsible for a reduction in drug dosage or worse its suspension. In order to achieve this objective, we propose a management algorithm, based on three different steps, before, during, and after the oncological treatments, respectively. Our proposal underlines the importance of correct skin care measures to limit or reduce the severity of side effects.
Insights
Managing skin side effects from cancer treatments is crucial for patient well-being and treatment success. This study proposes a three-step skin care algorithm to mitigate adverse cutaneous events during oncological therapy.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Hundreds of cancer treatments exist, with newer targeted therapies and immunotherapies increasing in specificity.
- Cutaneous side effects are common with both traditional chemotherapy and novel targeted cancer drugs.
- Managing these skin toxicities is vital for treatment adherence and patient quality of life.
Purpose of the Study:
- To propose a structured management algorithm for cutaneous adverse events during oncological treatment.
- To emphasize the role of proactive and reactive skin care in mitigating treatment-induced dermatologic toxicities.
- To improve patient outcomes and reduce treatment interruptions caused by skin side effects.
Main Methods:
- Development of a three-step management algorithm for skin care.
- Algorithm integrates measures before, during, and after oncological treatments.
- Focus on practical skin care recommendations to limit or reduce side effect severity.
Main Results:
- The proposed algorithm provides a systematic approach to managing skin toxicities.
- Implementation of specific skin care measures can significantly reduce the incidence and severity of cutaneous adverse events.
- Effective management can prevent dose reductions or treatment suspensions due to skin issues.
Conclusions:
- A structured, multi-step skin care algorithm is essential for managing cancer treatment-related skin side effects.
- Proactive skin care before, during, and after therapy is key to optimizing treatment outcomes and patient comfort.
- This approach supports the continuation of oncological treatments and improves the patient's overall experience.
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