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Updated: Dec 17, 2025
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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
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Association between Reflux Esophagitis Incidence and Palmar Hyperhidrosis
Chun-Gu Cheng1,2,3, Wu-Chien Chien4,5,6, Chia-Peng Yu6
1Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, National Defense Medical Center, Taoyuan 32549, Taiwan.
Summary
Palmar hyperhidrosis (PH) is linked to a higher risk of reflux esophagitis. This study found PH patients have a 3.46 times greater chance of developing reflux esophagitis.
Area of Science:
- Autonomic Nervous System
- Gastroenterology
- Dermatology
Background:
- Autonomic dysfunction in palmar hyperhidrosis (PH) involves sympathetic overactivity and parasympathetic impairment.
- Decreased parasympathetic tone is observed in gastroesophageal reflux disease (GERD).
- Patients with reflux esophagitis often exhibit a compromised anti-reflux barrier.
Purpose of the Study:
- To investigate the association between palmar hyperhidrosis and reflux esophagitis.
- To determine if PH is a risk factor for developing reflux esophagitis.
Main Methods:
- Utilized the National Health Insurance Database in Taiwan.
- Identified PH patients (ICD-9 code 780.8) and matched them with control groups by age and gender.
- Assessed reflux esophagitis incidence (ICD-9 codes 530.11, 530.81, 530.85) using Cox proportional regression analysis.
Main Results:
- Palmar hyperhidrosis patients demonstrated a significantly increased risk of reflux esophagitis.
- The adjusted hazard ratio for reflux esophagitis in PH patients was 3.457 (95% CI: 3.043-3.928).
Conclusions:
- Confirmed a significant association between palmar hyperhidrosis and reflux esophagitis.
- Healthcare providers should be aware of this link to optimize patient care and quality of life.
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