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Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies

Tamara Szabados1, Kamilla Gömöri1, Laura Pálvölgyi2

  • 1Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.

International Journal of Molecular Sciences
|June 27, 2020
PubMed

Insights

Activation of capsaicin-sensitive sensory nerves via the TRPV1 channel plays key roles in heart function and disease. Targeting these pathways may offer new treatments for cardiovascular diseases.

Area of Science:

  • Cardiology
  • Neuroscience
  • Physiology

Background:

  • Cardiovascular diseases are leading causes of death globally.
  • Capsaicin-sensitive sensory nerves and the TRPV1 channel are involved in cardiac regulation.
  • These nerves also influence cardiac disease progression and cardioprotection.

Purpose of the Study:

  • To review the role of capsaicin-sensitive afferents and TRPV1 in cardiac physiology and pathophysiology.
  • To explore the diagnostic and therapeutic potential of targeting these pathways.

Main Methods:

  • Review of experimental results on capsaicin-sensitive nerves and TRPV1 in the heart.
  • Analysis of physiological and pathophysiological functions.
  • Evaluation of diagnostic and therapeutic implications.

Main Results:

  • Activation of TRPV1-expressing sensory nerves has beneficial effects in cardiac diseases.
  • Neuropeptides released from these nerves play regulatory roles.
  • TRPV1 stimulation or overexpression shows promise for cardioprotection.

Conclusions:

  • TRPV1-expressing sensory nerves and TRPV1 channels have significant roles in cardiovascular health and disease.
  • Targeting TRPV1 offers potential therapeutic strategies for managing heart conditions.
Keywords:
acute myocardial infarctionarrhythmiaatherosclerosiscapsaicincardioprotectionheart failureischemic heart diseasetransient receptor potential vanilloid type 1 (TRPV1) receptor

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