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Malignant meningiomas.

Daniel M Fountain1, Adam M H Young1, Thomas Santarius1

  • 1Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, United Kingdom.

Handbook of Clinical Neurology
|June 27, 2020
PubMed
Summary

Malignant meningiomas (WHO Grade III) are rare, aggressive tumors with a poor prognosis. Developing novel therapies is crucial due to limited treatment options and the risks associated with surgery.

Keywords:
AnaplasticAnaplastic meningiomaMalignantMeningiomaPapillaryRadiotherapyRhabdoidSurgery

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Oncology

Background:

  • Malignant meningiomas, classified as WHO Grade III, constitute 1% of all meningiomas.
  • These tumors can develop initially or progress from lower-grade meningiomas.
  • Histologic subtypes include anaplastic, rhabdoid, and papillary types.

Purpose of the Study:

  • To highlight the challenges in understanding and treating malignant meningiomas.
  • To emphasize the need for novel therapeutic strategies.

Main Methods:

  • Review of existing literature on malignant meningiomas.
  • Analysis of treatment outcomes and challenges.

Main Results:

  • Malignant meningiomas have a poor prognosis with a 2-3 year overall survival rate.
  • Surgery is the primary treatment; radiotherapy may slow growth.
  • Current chemotherapeutic and targeted agent trials lack robust efficacy data.

Conclusions:

  • The rarity of these tumors hinders research into their natural history and effective treatments.
  • Alternative therapies are urgently needed due to the high risk of complications from repeated surgeries.