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External beam radiation therapy for meningioma.
1Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, United States.
Handbook of Clinical Neurology
|June 27, 2020
Summary
Radiation therapy (RT) is crucial for managing meningioma, especially for high-grade tumors or when surgery is not feasible. Studies are refining its role as adjuvant therapy for specific grades.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Meningioma management often involves surgery, but radiation therapy (RT) is a key treatment modality.
- RT is used as primary treatment for unresectable tumors or in patients unsuitable for surgery.
- It also serves as adjuvant therapy for incompletely resected or high-grade meningiomas.
Purpose of the Study:
- To review the role of fractionated external beam radiation therapy (RT) in managing various grades of meningioma.
- To discuss recent findings and ongoing trials that further define RT's application in meningioma treatment.
Main Methods:
- Review of existing literature and clinical trial data on radiation therapy for meningioma.
- Analysis of treatment outcomes based on meningioma grade and resection extent.
Main Results:
- Radiation therapy is effective in the primary treatment setting and as adjuvant therapy for meningioma.
- Recent studies, such as RTOG 0539, have strengthened the evidence for RT's role, including adjuvant RT for completely resected Grade II meningioma.
- Ongoing trials aim to further clarify optimal RT strategies.
Conclusions:
- Fractionated external beam RT is an important component in the multidisciplinary management of meningioma.
- Its application extends from primary treatment to adjuvant settings, with evolving evidence supporting its use in specific scenarios and grades.
