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Related Experiment Video

Updated: Dec 17, 2025

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
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Brachytherapy for meningiomas.

Stephen T Magill1, Theodore H Schwartz2, Philip V Theodosopoulos1

  • 1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.

Handbook of Clinical Neurology
|June 27, 2020
PubMed
Summary
This summary is machine-generated.

Interstitial brachytherapy using Iodine-125 implants is a potential treatment for recurrent high-grade meningiomas. While not definitively proven, case studies suggest it offers good long-term survival as an adjuvant therapy.

Keywords:
BrachytherapyHigh-gradeI-125Iodine-125MeningiomaRecurrent

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Recurrent high-grade meningiomas pose a significant treatment challenge.
  • Interstitial brachytherapy is an adjuvant treatment option following tumor resection.

Purpose of the Study:

  • To evaluate the role of interstitial intracranial radiotherapy implants (brachytherapy) as an adjuvant treatment for recurrent high-grade meningiomas.
  • To summarize current evidence regarding the efficacy and complications of brachytherapy in this patient population.

Main Methods:

  • Review of case series reporting on the use of brachytherapy for recurrent high-grade meningiomas.
  • Focus on the commonly used Iodine-125 (I-125) isotope.

Main Results:

  • Several case series report good long-term survival rates in patients treated with brachytherapy.
  • Brachytherapy is suggested as a potentially useful adjuvant therapy for recurrent high-grade meningiomas.

Conclusions:

  • Interstitial brachytherapy with Iodine-125 is a viable adjuvant option for recurrent high-grade meningiomas.
  • Potential complications include radiation necrosis, impaired wound healing, hydrocephalus, and infection.
  • Further research into new isotopes with improved safety profiles is ongoing.