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Related Concept Videos

Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrotic Syndrome III : Nursing Management01:24

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Primary Lymphoid Organs01:16

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Related Experiment Video

Updated: Dec 17, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Systemic lupus erythematosus 2020.

Javier Narváez1

  • 1Servicio de Reumatología, Hospital Universitario de Bellvitge-Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.

Medicina Clinica
|June 27, 2020
PubMed
Summary

Systemic lupus erythematosus (SLE) research is advancing with new classification criteria, biomarkers, and remission definitions. Emerging drugs and therapies offer improved treatment strategies for this complex autoimmune disease.

Keywords:
ActualizaciónBiomarcadoresBiomarkersClassification criteriaCriterios de clasificaciónLupus eritematoso sistémicoNew treatmentsNuevos tratamientosSystemic lupus erythematosusUpdate

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant morbidity.
  • Despite improved patient outlooks, unmet needs persist in SLE management.
  • Recent advancements necessitate an updated understanding of SLE diagnosis and treatment.

Purpose of the Study:

  • To review recent key developments in Systemic Lupus Erythematosus (SLE).
  • To summarize novel classification criteria, biomarkers, and remission definitions.
  • To discuss emerging therapeutic strategies and drugs for SLE.

Main Methods:

  • Literature review of recent scientific publications on SLE.
  • Analysis of new classification criteria from EULAR and ACR.
  • Synthesis of data on novel biomarkers and therapeutic advancements.

Main Results:

  • New classification criteria from EULAR and ACR enhance SLE diagnosis.
  • Novel biomarkers are emerging for SLE detection and monitoring.
  • New drugs and therapeutic strategies show promise for improved SLE management.

Conclusions:

  • Recent advancements are refining SLE classification and diagnosis.
  • Novel biomarkers and therapies offer new hope for SLE patients.
  • Continued research is crucial to address remaining unmet needs in SLE.