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Related Experiment Video

Updated: Jun 10, 2026

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

Variable Refocusing Flip Angle Single-Shot Imaging for Sedation-Free Fast Brain MRI.

R Jabarkheel¹, E Tong², E H Lee³

¹From the Stanford University School of Medicine (R.J.).

AJNR. American Journal of Neuroradiology

|June 27, 2020

Summary

This summary is machine-generated.

Variable refocusing flip angle single-shot FSE offers faster brain MRI scans with improved image quality. However, increased motion artifacts require careful consideration for clinical use.

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Area of Science:

Radiology
Medical Imaging
Neuroimaging

Background:

Conventional fast MRI techniques can yield suboptimal brain images.
Image quality issues include poor contrast, low signal-to-noise ratio (SNR), and blurring.

Purpose of the Study:

To evaluate the clinical performance of variable refocusing flip angle single-shot FSE (VRFA-SSFSE) as an alternative fast brain MRI method.
To compare VRFA-SSFSE with conventional single-shot FSE (SSFSE) and T2-FSE.

Main Methods:

Retrospective comparison of half-Fourier SSFSE, half- and full-Fourier VRFA-SSFSE in 30 children.
Image quality assessed for motion artifacts, brain-fluid interface sharpness, and gray-white differentiation.
Lesion detectability of full-Fourier VRFA-SSFSE compared to T2-FSE in 38 children.

Main Results:

VRFA-SSFSE showed increased motion artifacts (P < .001).
VRFA-SSFSE demonstrated superior image sharpness at brain-fluid interfaces and gray-white differentiation (P < .001).
VRFA-SSFSE achieved 47-53% faster acquisition times than SSFSE (P < .001).
Near-perfect agreement (κ = 0.90, 0.95) between full-Fourier VRFA-SSFSE and T2-FSE for lesion detection.

Conclusions:

VRFA-SSFSE provides significantly faster scan times and improved image sharpness for brain MRI.
Potential benefits include enhanced contrast, resolution, and SNR, reducing blurring.
Motion artifacts are a key consideration for VRFA-SSFSE clinical implementation.