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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.0K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.3K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Dec 17, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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Regenerative Therapy for Osteoarthritis: A Perspective.

Gun-Il Im1, Tae-Kyung Kim1

  • 1Research Institute for Integrative Regenerative Biomedical Engineering, Dongguk University, Goyang, Korea.

International Journal of Stem Cells
|June 27, 2020
PubMed
Summary

Regenerative medicine for osteoarthritis (OA) aims to repair damaged cartilage. Current cell therapies often fail due to rapid cell death, necessitating strategies for long-term cell survival for effective OA treatment.

Keywords:
ChondrogenicMesenchymal stem cellsOsteoarthritisRegenerative therapy

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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

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Related Experiment Videos

Last Updated: Dec 17, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

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Area of Science:

  • Regenerative medicine
  • Orthopedics
  • Biomedical engineering

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease with significant impact on quality of life.
  • Current treatments for OA lack disease-modifying capabilities, driving interest in regenerative approaches.
  • Articular cartilage (AC) damage in OA necessitates therapies that promote structural repair.

Purpose of the Study:

  • To review the history and current status of regenerative therapy for OA.
  • To outline strategies for improving the efficacy of cell-based OA treatments.
  • To discuss future directions for achieving structural modifications in OA.

Main Methods:

  • Perspective review of existing literature on OA regenerative therapies.
  • Analysis of cell survival, engraftment, and paracrine effects in OA treatment models.
  • Evaluation of current challenges and future opportunities in OA regenerative medicine.

Main Results:

  • Injected cells in suspension often undergo rapid apoptosis, limiting therapeutic benefits.
  • Transient paracrine effects of injected cells do not provide durable structural improvements.
  • Long-term cell survival and potential engraftment are critical for successful OA regenerative therapy.

Conclusions:

  • Current cell therapies for OA face challenges with cell survival and limited structural modification.
  • Achieving durable structural improvements in OA requires strategies ensuring prolonged cell function or engraftment.
  • Future research must focus on enhancing cell longevity and integration for effective OA regenerative treatments.