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Alprazolam dependence in seven patients
1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905.
The American Journal of Psychiatry
|May 1, 1988
Summary
This study found that seven patients developed psychoactive substance (alprazolam) dependence, experiencing withdrawal and tolerance. Many faced social impairment, highlighting the risks of alprazolam prescriptions.
Area of Science:
- Psychiatry
- Pharmacology
- Addiction Medicine
Background:
- Alprazolam is frequently prescribed for anxiety and depression.
- Assessing the potential for psychoactive substance dependence is crucial for patient safety.
Observation:
- Seven patients meeting DSM-III-R criteria for psychoactive substance dependence were identified.
- All patients experienced withdrawal symptoms, and six showed tolerance to alprazolam.
- At least four patients exhibited significant social or occupational impairment due to alprazolam use.
Findings:
- Patients initiated alprazolam for anxiety or depression, with doses ranging from 2-12 mg/day over 6 months to 3 years.
- Co-occurring or past abuse of other substances was noted in six patients.
- The study highlights a clear link between therapeutic alprazolam use and subsequent dependence.
Implications:
- Clinicians should carefully consider the risk of alprazolam dependence, especially in patients with a history of substance abuse.
- Further research into the long-term effects and dependence potential of benzodiazepines like alprazolam is warranted.
- Patient monitoring and alternative treatment strategies may be necessary to mitigate risks associated with alprazolam therapy.
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