Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary epidermal growth factor concentrations in various human malignancies.

A L Mattila1, I Saario, L Viinikka

  • 1Children's Hospital, Helsinki, Finland.

British Journal of Cancer
|February 1, 1988
PubMed
Summary

Urine epidermal growth factor (U-irEGF) levels are higher in female cancer patients, particularly those with endometrial carcinoma. This finding may aid in diagnosing malignancies in women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood.

Journal of clinical immunology·2013
Same author

TSGA10 - A target for autoantibodies in autoimmune polyendocrine syndrome type 1 and systemic lupus erythematosus.

Scandinavian journal of immunology·2011
Same author

Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR.

Genes and immunity·2010
Same author

Autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED)--a diagnostic and therapeutic challenge.

Pediatric endocrinology reviews : PER·2010
Same author

Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I.

Journal of internal medicine·2009
Same author

Bone health in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): findings in 25 adults.

Clinical endocrinology·2006

Area of Science:

  • Oncology
  • Biochemistry
  • Urology

Background:

  • Epidermal growth factor (EGF) plays a role in cell growth and is implicated in various cancers.
  • Urinary immunoreactive EGF (U-irEGF) levels may serve as a potential biomarker for malignancy.

Purpose of the Study:

  • To investigate U-irEGF concentrations in patients with diverse malignancies.
  • To compare U-irEGF levels between cancer patients and healthy controls, stratified by sex.

Main Methods:

  • Quantification of U-irEGF concentrations in urine samples from 97 adult cancer patients and healthy controls.
  • Normalization of U-irEGF levels to creatinine.
  • Statistical analysis to compare patient groups and controls.

Main Results:

Related Experiment Videos

  • Overall higher U-irEGF concentrations were observed in female cancer patients compared to age- and sex-matched healthy controls (P = 0.002).
  • No significant difference in U-irEGF levels was found between male cancer patients and controls.
  • Women with endometrial carcinoma exhibited statistically significantly elevated U-irEGF levels (P = 0.0005).

Conclusions:

  • Elevated U-irEGF may indicate malignancy in women.
  • U-irEGF shows potential as a non-invasive biomarker for detecting endometrial carcinoma.