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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Opioid Receptors: Overview01:22

Opioid Receptors: Overview

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Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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Related Experiment Video

Updated: Dec 17, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Non-coding RNAs in neuropathic pain.

Theodora Kalpachidou1, Kai K Kummer1, Michaela Kress1

  • 1Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.

Neuronal Signaling
|June 27, 2020
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are key regulators in chronic pain. Their unique expression signatures offer potential for diagnosing and treating neuropathic pain.

Keywords:
lncRNAmicroRNAneuroimmune interationsneuropathic painnon-coding RNA

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Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons
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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Immunology

Background:

  • Chronic pain involves neuro-immune alterations in the nervous system.
  • Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are critical regulators of neuronal and immune processes.
  • Dysregulated ncRNA expression is linked to various chronic disorders, suggesting diagnostic potential.

Purpose of the Study:

  • To explore the role of ncRNAs in the pathophysiology of chronic pain.
  • To investigate the potential of ncRNAs as diagnostic biomarkers for neuropathic pain.
  • To examine ncRNA-mediated therapeutic strategies for pain management.

Main Methods:

  • Review of existing literature on ncRNAs in neuropathic pain.
  • Analysis of miRNA and lncRNA expression patterns in chronic pain models and patients.
  • Investigation of ncRNA mechanisms in neuronal and glial cells.

Main Results:

  • Specific miRNAs regulate key processes in neurons, immune cells, and glia involved in neuropathic pain.
  • lncRNAs are implicated in purinergic signaling pathways in the nervous system.
  • ncRNA expression signatures show promise for diagnostic applications in neuropathic pain.

Conclusions:

  • ncRNAs, particularly miRNAs and lncRNAs, are crucial in chronic pain pathogenesis.
  • lncRNAs may serve as biomarkers for neuropathic pain in liquid biopsies.
  • Therapeutic strategies targeting miRNA function present a promising avenue for pain treatment.