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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
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KIF18B promotes tumor progression in osteosarcoma by activating β-catenin
Tian Gao1, Ling Yu2, Zhiwei Fang1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Bone and Soft Tissue Tumor, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Cancer Biology & Medicine
|June 27, 2020
Summary
Kinesin family member 18B (KIF18B) is overexpressed in osteosarcoma, promoting cancer growth and spread. Inhibiting KIF18B halts tumor progression and suggests its potential as a biomarker for this bone cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Osteosarcoma is a malignant bone tumor.
- Kinesin family member 18B (KIF18B) is implicated in various cancers.
- KIF18B overexpression is observed in osteosarcoma, but its role is unclear.
Purpose of the Study:
- To investigate the function of KIF18B in osteosarcoma.
- To assess KIF18B's impact on osteosarcoma cell proliferation, migration, and invasion.
- To explore the molecular mechanisms underlying KIF18B's role in osteosarcoma.
Main Methods:
- Assessed KIF18B expression in osteosarcoma tissues and cells.
- Evaluated the effects of KIF18B knockdown on cell proliferation, migration, and invasion in vitro and in vivo.
- Investigated KIF18B's regulation of beta-catenin, ATF2, and APC interactions.
Main Results:
- KIF18B was significantly overexpressed in osteosarcoma.
- KIF18B knockdown inhibited osteosarcoma cell proliferation, migration, and invasion.
- KIF18B regulates beta-catenin via ATF2 nuclear aggregation and APC interaction.
Conclusions:
- KIF18B promotes osteosarcoma development and metastasis.
- KIF18B acts as an oncogene by modulating beta-catenin expression.
- KIF18B is a potential prognostic biomarker for osteosarcoma.
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