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Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike
Biorxiv : the Preprint Server for Biology
|June 27, 2020
Summary
Researchers isolated 61 SARS-CoV-2-neutralizing monoclonal antibodies from patients. Nineteen antibodies potently neutralized the virus, with nine showing exquisite potency, offering promising therapeutic candidates.
Area of Science:
- Virology
- Immunology
- Structural Biology
Background:
- The SARS-CoV-2 pandemic has caused severe global health and economic impacts.
- Monoclonal antibodies are a potential therapeutic strategy against SARS-CoV-2 infection.
Conclusions:
- The identified monoclonal antibodies, particularly those with high potency, are promising candidates for SARS-CoV-2 therapeutic and prophylactic applications.
- Both RBD and NTD are immunogenic targets for neutralizing antibodies.
- Structural analysis provides insights into antibody-spike interactions and potential mechanisms of neutralization.
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