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Related Experiment Videos

Failure to demonstrate complement activation during bronchial challenge test.

O Michel1, J Duchateau, R Sergysels

  • 1Pulmonary Division (Development of Internal Medicine), Saint-Pierre University Hospital, Brussels, Belgium.

The European Respiratory Journal
|February 1, 1988
PubMed
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Complement activation was not detected in the blood during early asthma reactions. Further lung-specific studies are needed to fully understand complement

Area of Science:

  • Immunology
  • Pulmonology
  • Allergy

Background:

  • Asthma involves bronchospastic reactions.
  • Complement activation is a potential factor in allergic inflammation.
  • C3d and C3d/C3 index are indicators of complement activation.

Purpose of the Study:

  • To investigate complement activation during early bronchospastic reactions in asthma.
  • To measure plasmatic C3d and the C3d/C3 index in asthmatic patients.

Main Methods:

  • Conducted 29 allergenic bronchial challenge tests.
  • Measured plasmatic C3d and C3d/C3 index at specific time points.
  • Categorized responses into no reaction, early reaction, and dual reaction.

Main Results:

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  • No significant changes in plasmatic C3d or C3d/C3 index were observed five minutes after an early reaction.
  • No significant changes were noted five minutes after allergen exposure in non-responders.
  • These findings suggest a lack of systemic complement activation during early asthmatic responses.

Conclusions:

  • Systemic complement activation was not demonstrated in the blood during early asthmatic bronchospastic reactions.
  • Complement activation within the lungs during asthma cannot be ruled out without bronchoalveolar lavage studies.