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Molecular and Biological Functions of Quercetin as a Natural Solution for Cardiovascular Disease Prevention and
Liaosadat Mirsafaei1, Željko Reiner2, Rana Shafabakhsh3
1Department of Cardiology, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran.
Insights
Quercetin, a natural compound found in foods, shows promise in preventing cardiovascular disease (CVD). Research indicates its cardioprotective effects, potentially by lowering blood pressure and acting as an antioxidant.
Area of Science:
- Nutritional Science
- Cardiology
- Pharmacology
Background:
- Cardiovascular disease (CVD) presents a significant global health challenge, with increasing mortality and morbidity.
- Key risk factors for CVD include hypertension, smoking, diabetes, obesity, and dyslipidemia.
- Preventive measures involve lifestyle modifications like smoking cessation, weight management, physical activity, and dietary adjustments.
Purpose of the Study:
- To review experimental and clinical studies on the effects of quercetin in cardiovascular disease (CVD).
- To summarize the molecular mechanisms underlying quercetin's cardioprotective actions.
- To evaluate the clinical efficacy of quercetin for CVD prevention and management.
Main Methods:
- Comprehensive literature search of in vitro, in vivo, and human clinical trials.
- Analysis of studies investigating quercetin's impact on cardiovascular risk factors.
- Evaluation of research detailing quercetin's antioxidant and anti-inflammatory pathways.
Main Results:
- Numerous studies demonstrate quercetin's cardioprotective properties.
- Quercetin exhibits potential in reducing blood pressure and possesses significant antioxidant capabilities.
- Evidence suggests quercetin may mitigate CVD through various molecular mechanisms.
Conclusions:
- Quercetin is a promising dietary compound with demonstrated cardioprotective effects.
- Further clinical research is warranted to establish optimal quercetin dosages and therapeutic applications for CVD.
- Dietary intake of quercetin-rich foods may contribute to cardiovascular health.
Abstract:
Cardiovascular disease (CVD) is a worldwide health problem with growing up rates of mortality and morbidity. Many risk factors, including high blood pressure, cigarette smoking, diabetes, obesity, and dyslipidemia are responsible for CVD. CVD can be prevented by some simple and cost-effective steps such as smoking cessation, normalizing body weight, regular physical activity, and dietary changes, including decreasing saturated fats, increasing the intake of vegetables and fruits, and reducing sugar intake. In the last decades, growing up number of studies were performed to explain the possible function of non-nutrient substances from the diet which might prevent CVD. One of these natural compounds is quercetin which is widely present in vegetables, tea, fruits and wine. Many in vitro, in vivo and clinical studies have indicated the cardioprotective functions of quercetin. They can be explained by quercetin's reducing blood pressure, antioxidant potential and some other activities. This review evaluates the experimental and clinical studies that have studied the effect of quercetin in CVD and summarizes the molecular mechanisms of action as well as clinical effects of quercetin in CVD.
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