Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic studies in Darier's disease.

S Halevy1, S Weltfriend, A I Pick

  • 1Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.

International Journal of Dermatology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spinal anesthesia in a patient with prekallikrein deficiency.

Anesthesia and analgesia·1996
Same author

Predictors of sun exposure in adolescents in a southeastern U.S. population.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine·1996
Same author

Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.

Annals of internal medicine·1996
Same author

The Endophthalmitis Vitrectomy Study.

Archives of ophthalmology (Chicago, Ill. : 1960)·1996
Same author

Regulation of glucose turnover and hormonal responses during electrical cycling in tetraplegic humans.

The American journal of physiology·1996
Same author

[Ultrasound diagnosis of acute appendicitis--possibilities and limits of the method--results of prospective and retrospective clinical studies].

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·1996
Same journal

Updated Vitiligo Trends in the Burden of Psychiatric and Autoimmune Diseases.

International journal of dermatology·2026
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
See all related articles

This study found normal immune cell levels in Darier's disease patients, but noted altered lymphocyte responses in vitro, suggesting potential immune regulation or membrane function changes. The exact role in disease pathogenesis remains unclear.

Area of Science:

  • Immunology
  • Dermatology
  • Genetics

Background:

  • Darier's disease is a rare genetic skin disorder.
  • Its association with immune system dysregulation is not well understood.

Purpose of the Study:

  • To investigate humoral and cellular immunity in patients with Darier's disease.
  • To explore potential immune system alterations contributing to the disease.

Main Methods:

  • Evaluated serum immunoglobulins, complement, and peripheral immune cells (macrophages, B and T lymphocytes) in 10 patients.
  • Assessed delayed hypersensitivity skin tests and lymphocyte transformation responses to PHA and ConA.

Main Results:

  • Most immune parameters were within normal limits.

Related Experiment Videos

  • One patient showed complete anergy to skin tests.
  • Lymphocyte transformation tests revealed enhanced responsiveness to mitogens.

    • Conclusions:

    • Findings suggest possible alterations in immunoregulation or lymphocyte membrane function in Darier's disease.
    • The clinical significance of these immunologic aberrations requires further investigation.