Testing nonlinearity in topological organization of functional brain networks

Aiming to provide an argumentation on the underlying nonlinearity of the overall functional brain network via surrogate data method and graph theory. Taking the functional magnetic resonance imaging data as original data set and then shuffled the time series of each region of interest to generate surrogate data sets, corresponding original network and its 400 surrogates were obtained via computing connectivity matrixes. The results show that both the global correlation level and corresponding small-world topological characters exhibited obvious differences between the original network and its surrogates. And the following statistical testing results demonstrate their significant distinction, and this topological difference has been proved to be caused by the intrinsic nonlinear dynamics. Accordingly, the nonlinearity of the original functional network and its superior dynamical complexity have been confirmed. The results of this study could provide a novel angle into exploring the underlying mechanism of the neural brain system and offer an essential evidence in explaining complex brain activities.