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Updated: Dec 17, 2025

Rapid Isolation of the Mitoribosome from HEK Cells
Published on: October 4, 2018
Loading messenger RNAs onto ribosomes in human mitochondria: lessons learned from a bacterial toxin
Lukasz S Borowski1,2, Roman J Szczesny1
1Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.
Abstract:
Mitochondria are peculiar organelles because their function depends on genetic information that is present in two genomes: nuclear and mitochondrial. The expression of mitochondrially encoded information requires dedicated machinery. Many efforts have been made to identify this machinery and describe its relevant mechanisms. Recently, Bruni et al. reported a cellular model that they established to investigate the pathway for loading messenger RNAs onto ribosomes in human mitochondria. Their study revealed a role for monosome formation in the stability of mitochondrial mRNAs. Comment on: https://doi.org/10.1111/febs.15342.
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