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Plasma P-selectin level is associated with severity of coronary heart disease in Chinese Han population

Chunhui Song1,2, Guohai Wu2, Sheng Chang2

  • 1Department of Cardiology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

The Journal of International Medical Research
|June 27, 2020
PubMed

Insights

Plasma P-selectin levels are elevated in Chinese Han patients with coronary heart disease (CHD). Higher P-selectin indicates greater CHD severity and identifies it as an independent risk factor.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Clinical Research

Background:

  • Coronary heart disease (CHD) poses a significant health burden.
  • Identifying reliable biomarkers for CHD severity is crucial for patient management.

Purpose of the Study:

  • To investigate the association between plasma P-selectin levels and CHD severity.
  • To assess P-selectin as a potential biomarker in a Chinese Han population.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify plasma P-selectin.
  • Coronary stenosis was assessed by the number of diseased arteries and Gensini score.
  • Comparative analysis was performed between 219 CHD patients and 168 healthy controls.

Main Results:

  • P-selectin levels were significantly higher in CHD patients versus controls.
  • P-selectin levels correlated positively with the number of diseased vessels and Gensini score.
  • Elevated P-selectin was identified as an independent risk factor for CHD.

Conclusions:

  • Plasma P-selectin is elevated in Chinese Han patients with CHD.
  • P-selectin levels reflect CHD severity and serve as an independent risk factor.
  • P-selectin may be a valuable biomarker for assessing CHD severity in this population.
Abstract

Keywords:
C-reactive proteinGensini scoreP-selectincoronary heart diseaseplasma levelrisk factor

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