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Updated: Dec 17, 2025

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An integrated platform for fibrinogen quantification on a microfluidic paper-based analytical device.

Yanfang Guan1, Kun Zhang, Fengqian Xu

  • 1College of Electromechanical Engineering, Henan University of Technology, Zhengzhou 450001, China. yguan@haut.edu.cn.

Lab on a Chip
|June 27, 2020
PubMed
Summary

A new microfluidic paper-based device offers a simple, rapid, and low-cost method for detecting fibrinogen (FIB) levels. This innovative platform provides accurate FIB detection, aiding in the diagnosis and management of various health conditions.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Fibrinogen (FIB) is crucial for blood coagulation and thrombosis, making its detection vital for managing liver and heart diseases.
  • Current FIB detection methods are often expensive, complex, and time-consuming, limiting their accessibility.

Purpose of the Study:

  • To develop a novel, low-cost, and user-friendly platform for sensitive plasma separation and FIB detection.
  • To address the need for rapid and accessible diagnostic tools, particularly in resource-limited settings.

Main Methods:

  • A microfluidic paper-based analytical device (μPAD) integrating dielectrophoretic (DEP) and capillary forces for efficient plasma separation (approx. 95% efficiency).
  • Introduction of a new resistance-fibrinogen detection (RFD) method for FIB quantification without large instruments.
  • Validation of the RFD method across a FIB concentration range of 127.0 to 508.0 mg dL⁻¹.

Main Results:

  • The μPAD achieved high plasma separation efficiency, ensuring reliable downstream FIB analysis.
  • The RFD method demonstrated high precision and simplicity, correlating excellently (R² = 0.9985) with automated coagulation analyzers.
  • The platform proved reliable for detecting a wide range of FIB concentrations in natural human blood samples.

Conclusions:

  • The proposed μPAD platform offers a cost-effective and reliable solution for FIB detection.
  • This technology has significant potential for clinical applications, especially in resource-limited areas requiring rapid and accessible diagnostics.