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Humanized Mouse Models for Evaluation of PSC Immunogenicity.

Jack Hermsen1, Matthew E Brown1

  • 1University of Wisconsin School of Medicine and Public Health Western Clinical Campus, Madison, Wisconsin.

Current Protocols in Stem Cell Biology
|June 27, 2020
PubMed
Summary

Investigating the human immune response to human pluripotent stem cell (hPSC) therapies is crucial. Humanized mouse models offer a valuable tool for understanding hPSC immunogenicity in regenerative medicine research.

Keywords:
humanized micepluripotent stem cell immunogenicitytransplantation immunology

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Area of Science:

  • Regenerative Medicine
  • Immunology
  • Stem Cell Biology

Background:

  • Human pluripotent stem cell (hPSC)-derived therapies are progressing rapidly towards clinical application.
  • A significant challenge is understanding and mitigating the human immune response to these cell therapies, which can lead to rejection.
  • Evaluating hPSC immunogenicity is critical for the success of these novel treatments.

Purpose of the Study:

  • To provide an overview of humanized mouse models for studying hPSC immunogenicity.
  • To discuss key considerations for researchers using these models.
  • To highlight the importance of understanding immune responses in regenerative medicine.

Main Methods:

  • Review of existing literature on humanized mouse models.
  • Discussion of in vitro and in vivo assays for evaluating immune responses.
  • Focus on models engrafted with human immune cells.

Main Results:

  • Humanized mouse models are essential for investigating the adaptive immune response to hPSC therapies.
  • These models allow for detailed study of immune mechanisms against cell therapies.
  • The article serves as a guide for selecting and utilizing appropriate models.

Conclusions:

  • Humanized mouse models are indispensable tools for assessing hPSC immunogenicity.
  • Understanding immune responses is vital for advancing hPSC-based regenerative medicine.
  • Further research utilizing these models will facilitate the clinical translation of hPSC therapies.