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Bone marrow contribution to the heart from development to adulthood

Vasco Sampaio-Pinto1, Adrián Ruiz-Villalba2, Diana S Nascimento3

  • 1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Maastricht, the Netherlands.

Seminars in Cell & Developmental Biology
|June 28, 2020
PubMed

Insights

Bone marrow-derived cells continuously infiltrate the heart, maintaining tissue health and influencing cardiac disease. Understanding these blood cells is key for developing new heart regeneration therapies.

Area of Science:

  • Cardiovascular Biology
  • Hematology
  • Tissue Engineering

Background:

  • Cardiac tissue harbors diverse non-contractile interstitial cells, including significant populations of blood lineage-derived cells.
  • Blood cells colonize heart tissue before birth and are continuously recruited from the bone marrow throughout life.
  • Bone marrow is the primary source for replenishing circulating cells, playing a crucial role in cardiac cell incorporation.

Purpose of the Study:

  • To comprehensively review the functions of bone marrow-derived blood cells within the heart.
  • To explore the role of these cells in both steady-state cardiac homeostasis and disease progression.
  • To discuss their relevance in emerging cardiovascular research areas, such as cell-based heart regeneration.

Main Methods:

  • This review synthesizes existing literature on bone marrow-derived cells in the cardiovascular system.
  • It integrates findings from hematology, cardiology, and regenerative medicine research.
  • No new experimental data were generated; this is a review article.

Main Results:

  • Bone marrow-derived cells are integral to normal heart function and tissue maintenance.
  • These cells significantly impact the development and progression of cardiac diseases.
  • Their continuous recruitment highlights a dynamic interaction between the bone marrow and the heart.

Conclusions:

  • Bone marrow-derived cells are critical players in cardiac physiology and pathology.
  • Targeting or utilizing these cells holds promise for novel therapeutic strategies in cardiovascular medicine.
  • Further research into bone marrow-derived cell functions is essential for advancing cell-based heart regeneration.

Keywords:
Blood lineagesCardiac diseaseFetal and adult hematopoiesisHeart tissue homeostasis

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