Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Adult Stem Cells01:33

Adult Stem Cells

33.1K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.1K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the quality of systematic reviews and meta-analyses published in behaviour analysis journals: An umbrella review.

PloS one·2026
Same author

Impact of Sex on Prediction of Asthma Attacks by Clinical Risk Factors and Type 2 Biomarkers.

Chest·2026
Same author

Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.

Respiratory research·2026
Same author

Hypoxia promotes airway differentiation in the human lung epithelium.

Cell stem cell·2025
Same author

Effect of tezepelumab on asthma exacerbations co-occurring with infection-attributed acute respiratory illnesses.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same author

mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

Nature communications·2025
Same journal

A tri-axis optomechanical accelerometer with plasmonic MIM waveguide and structural direction-dependent optical signatures.

Scientific reports·2026
Same journal

Holographic leaky-wave antennas with independently controlled multiple counter-rotating vortex beams.

Scientific reports·2026
Same journal

Differential associations of longitudinal hearing and vision trajectories with dementia and mild cognitive impairment in older adults.

Scientific reports·2026
Same journal

Abdominal obesity and leisure-time sedentary behavior in relation to gastroesophageal reflux disease risk: a prospective cohort study from the UK Biobank.

Scientific reports·2026
Same journal

Effect of nitrogen-rich COF incorporation on the structure and separation performance of polyamide nanofiltration membranes.

Scientific reports·2026
Same journal

Withanolide A inhibits hIAPP aggregation: An In silico, biophysical, and drosophila-based In vivo validation.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Dec 17, 2025

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.8K

Distal lung epithelial progenitor cell function declines with age.

Julie K Watson1, Philip Sanders2, Rebecca Dunmore2

  • 1Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. jwlz101@yahoo.co.uk.

Scientific Reports
|June 28, 2020
PubMed
Summary
This summary is machine-generated.

Aging causes lung stem cell exhaustion, slowing cellular turnover in bronchiolar and alveolar progenitor cells. This study reveals age-related changes impacting lung function and disease risk.

More Related Videos

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

9.4K
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.0K

Related Experiment Videos

Last Updated: Dec 17, 2025

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.8K
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

9.4K
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.0K

Area of Science:

  • Pulmonary Medicine
  • Aging Research
  • Stem Cell Biology

Background:

  • Tissue stem cell exhaustion is a primary indicator of aging.
  • Understanding age-related lung changes is crucial for addressing pulmonary diseases.

Purpose of the Study:

  • To characterize the manifestation of stem cell exhaustion in the distal lung.
  • To investigate age-related changes in lung epithelial progenitor populations and gene expression.
  • To elucidate the contribution of lung stem cell dynamics to age-related functional decline and disease.

Main Methods:

  • Comparative analysis of lung tissue from young (3-month) and old (22-month) mice.
  • Gross morphological examination, assessment of epithelial progenitor cell density and function (EdU incorporation, immunohistochemistry).
  • Microarray analysis of epithelial gene expression profiles, focusing on proliferation, differentiation, and signaling pathways (IGF, TGFβ).

Main Results:

  • Bronchioles showed reduced cross-sectional area and diameter with aging.
  • Bronchiolar club progenitor cell self-renewal and differentiation rates decreased, indicating slower cellular turnover.
  • Alveolar Type II progenitor cell self-renewal was maintained, but differentiation into Type I cells and Type I cell density were reduced.
  • Microarray analysis identified age-related gene expression changes in proliferation, differentiation, and IGF/TGFβ signaling.

Conclusions:

  • Aging leads to reduced cellular turnover in lung epithelial progenitor populations.
  • Age-related alterations in stem cell dynamics contribute to diminished lung function.
  • These findings provide insights into the pathogenesis of age-related pulmonary diseases.