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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Updated: Dec 17, 2025

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Exploring the periodontal disease-ischemic stroke link.

Souvik Sen1, Rachel Mascari1

  • 1Department of Neurology, School of Medicine, University of South Carolina, Columbia, SC.

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|June 28, 2020
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Summary

Periodontal disease is a significant risk factor for ischemic stroke and cardiovascular events. Treating gum disease may help reduce the risk of recurrent cardiovascular events in stroke survivors.

Keywords:
atherosclerosisatrial fibrillationcerebrovascular disordersinflammationischemic strokeperiodontal disease

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Area of Science:

  • Cardiovascular Science
  • Neurology
  • Periodontology

Background:

  • Ischemic stroke is a leading cause of disability and death.
  • Multiple risk factors contribute to ischemic stroke.
  • Periodontal disease is a common inflammatory condition affecting the gums and supporting bone.

Purpose of the Study:

  • To review the association between periodontal disease and ischemic stroke.
  • To highlight the role of periodontal disease in cardiovascular events.
  • To describe a clinical trial investigating periodontal disease treatment for stroke patients.

Main Methods:

  • Literature review of studies on periodontal disease and stroke.
  • Analysis of existing research on cardiovascular event risk.
  • Description of an ongoing clinical trial protocol.

Main Results:

  • Periodontal disease is significantly linked to increased risk of primary ischemic stroke.
  • Periodontal disease is associated with higher risk of subsequent cardiovascular events.
  • Evidence suggests a link between periodontal disease and various causes of ischemic stroke.

Conclusions:

  • Periodontal disease is a modifiable risk factor for ischemic stroke.
  • Treatment of periodontal disease may be a viable strategy to reduce cardiovascular risk in stroke patients.
  • Further research and clinical trials are warranted to confirm these findings.