Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Reticular Dermis01:15

Reticular Dermis

4.3K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.3K
Papillary Dermis01:11

Papillary Dermis

5.2K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.2K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

3.6K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
3.6K
Pigmentation01:19

Pigmentation

4.0K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-discontinuation recurrence following hydroxychloroquine-induced clearance in granuloma annulare.

Journal of the American Academy of Dermatology·2026
Same author

Extrafacial involvement in lupus miliaris disseminatus faciei.

JAAD case reports·2026
Same author

Granuloma annulare: An updated review of epidemiology, molecular pathogenesis, and management.

Journal of the American Academy of Dermatology·2026
Same author

Artificial intelligence in dermatology: Clinical promise and environmental impact.

The Journal of investigative dermatology·2026
Same author

Presentation, Diagnosis, and Treatment of Cutaneous Crohn Disease.

JAMA dermatology·2026
Same author

Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial.

JAMA dermatology·2026

Related Experiment Video

Updated: Dec 17, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

676

Cutaneous Sarcoidosis.

Avrom Caplan1, Misha Rosenbach2, Sotonye Imadojemu3

  • 1Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, New York.

Seminars in Respiratory and Critical Care Medicine
|June 28, 2020
PubMed
Summary
This summary is machine-generated.

Sarcoidosis is a chronic inflammatory disease affecting multiple organs, commonly the lungs and skin. Understanding varied skin manifestations is key for diagnosis and prognosis.

More Related Videos

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

445
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.8K

Related Experiment Videos

Last Updated: Dec 17, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

676
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

445
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.8K

Area of Science:

  • Immunology
  • Dermatology
  • Pulmonology

Background:

  • Sarcoidosis is a multisystem inflammatory disease of unknown cause.
  • Characterized by noncaseating granulomas affecting organ function.
  • The lungs are most commonly affected, followed by the skin.

Purpose of the Study:

  • To explore the diverse clinical presentations of cutaneous sarcoidosis.
  • To understand the relationship between skin morphology and disease prognosis.
  • To highlight the role of skin findings in sarcoidosis diagnosis and management.

Main Methods:

  • Review of clinical presentations of cutaneous sarcoidosis.
  • Classification of skin findings into 'specific' and 'nonspecific' types.
  • Discussion of diagnostic and therapeutic implications.

Main Results:

  • Cutaneous sarcoidosis presents with highly variable manifestations.
  • Skin involvement can be the primary sign or a later development.
  • Findings can be 'specific' (granulomas in skin) or 'nonspecific' (reactive inflammation).

Conclusions:

  • Cutaneous sarcoidosis is a significant manifestation with variable clinical impact.
  • Skin findings are crucial for diagnosis, potentially guiding therapy.
  • Effective, universally applicable treatments remain a challenge.