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Antihypertensive medications and physical function in older persons
Carlos A Vaz Fragoso1, Gail J McAvay2
1VA Connecticut, West Haven, CT, United States of America; Yale School of Medicine, Department of Medicine, New Haven, CT, United States of America.
Experimental Gerontology
|June 29, 2020
Summary
Beta blockers and multiple antihypertensives are linked to increased sedentary time in older adults. This finding highlights potential risks associated with these medications in aging populations.
Area of Science:
- Gerontology
- Pharmacology
- Physical Medicine
Background:
- Medications can impact physical function in aging populations.
- Understanding antihypertensive (antiHTN) effects on physical function is crucial.
Purpose of the Study:
- To evaluate associations between antihypertensive medication class and number used with physical function, mobility, sedentary time, and symptoms in older adults.
Main Methods:
- Utilized baseline data from the Lifestyle Interventions and Independence in Elder (LIFE) study (N=1567).
- Employed multivariable models to assess cross-sectional associations of antiHTN class and number with physical measures and symptom questionnaires.
- Included measures of muscle strength, balance, gait speed, mobility, sedentary time, dyspnea, and fatigue.
Main Results:
- Nearly 80% of participants used at least one antiHTN medication.
- Use of beta blockers (BB) was associated with a 44% increased odds of high sedentary time.
- Using three or more antiHTNs was associated with a 52% increased odds of high sedentary time.
Conclusions:
- Beta blocker use and polypharmacy with antihypertensives are linked to increased sedentary time in older adults.
- High sedentary time is a risk factor for adverse health outcomes.
- Further research is needed to determine if sedentary time modifies antiHTN benefits or risks in aging populations.
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