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Updated: Dec 17, 2025
In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
Central motor conduction time reveals upper motor neuron involvement masked by lower motor neuron impairment in a
Ryo Tokimura1, Takenobu Murakami2, Yoshikazu Ugawa3
1Department of Neurology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Japan.
Objective:
We retrospectively investigated the utility of the central motor conduction time (CMCT) in detecting upper motor neuron (UMN) involvements in patients with amyotrophic lateral sclerosis (ALS).
Methods:
Fifty-two ALS patients and 12 disease control patients participated in this study. Surface electromyograms were recorded from the first dorsal interosseous (FDI) and tibialis anterior (TA) muscles. We stimulated the motor cortex, brainstem, and spinal nerve using transcranial magnetic stimulation (TMS) in order to measure the cortical, brainstem, and spinal latencies. We divided the ALS patients into 2 subgroups (with UMN impairment vs. without UMN impairment) and calculated the rates of abnormal CMCT prolongation judged by their comparison with the normal ranges obtained by the measurement in the control patients.
Results:
The CMCTs in the FDI and TA were abnormally prolonged in over 40% of the ALS patients with UMN impairment and in nearly 30% of those without UMN impairment.
Conclusions:
CMCT shows UMN dysfunction in ALS patients without clinical UMN impairment.
Significance:
TMS still has diagnostic utility in a significant portion of ALS patients.
