Implications of NAD⁺ boosters in translational medicine

Nicotinamide adenine dinucleotide (NAD⁺ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, poly (ADP-ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD⁺ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD⁺ . The therapeutic potential of dietarily available NAD⁺ boosters preserving the NAD⁺ pool has been attracting attention after the discovery of declining NAD⁺ levels in ageing model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD⁺ , including the salubrious effects of NAD⁺ boosters and discuss their future translational strategies.