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Flow Cytometric Characterization of Murine B Cell Development
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Putative role of marginal zone B cells in pathophysiological processes.

Dragan Marinkovic1, Tatjana Marinkovic2

  • 1Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia.

Scandinavian Journal of Immunology
|June 29, 2020
PubMed
Summary

Marginal zone B cells bridge innate and adaptive immunity, acting as sentinels against blood-borne pathogens and regulating autoimmune responses. These cells are crucial for maintaining organism integrity and can be involved in MALT lymphoma development.

Keywords:
autoimmunityinfectionlymphomamarginal zone B cells

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Organism integrity relies on innate and adaptive immunity.
  • Marginal zone B cells (MZB cells) uniquely link these two branches.
  • MZB cells are strategically located for filtering blood and lymph.

Purpose of the Study:

  • To explore the complex biology of marginal zone B cells.
  • To elucidate their role in directing innate and adaptive immune responses.
  • To understand their involvement in physiological and pathological processes.

Main Methods:

  • The study is a review of existing literature on MZB cells.
  • It synthesizes information on their development, function, and pathological implications.
  • No new experimental data was generated.

Main Results:

  • MZB cells rapidly respond to blood-borne antigens, differentiating into IgM plasmablasts.
  • They possess the intrinsic ability to induce CD4+ T cell responses and cytokine production.
  • MZB cells can act as regulatory cells in autoimmunity and may transform into MALT lymphoma.

Conclusions:

  • MZB cells are critical connectors between innate and adaptive immunity.
  • They play a dual role in host defense and immune regulation.
  • Their dysregulation is linked to autoimmunity and malignancy, highlighting their complex biological significance.