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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
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Hypoxic tumor microenvironment: Implications for cancer therapy

Sukanya Roy1, Subhashree Kumaravel1, Ankith Sharma1

  • 1Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, TX 77807, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|June 30, 2020
PubMed
Abstract

Insights

Hypoxia, or low oxygen, fuels tumor growth and resistance to cancer treatments. Understanding hypoxia

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Hypoxia is a critical factor in solid tumor progression.
  • It drives tumor aggressiveness and resistance to therapies.
  • Tumor hypoxia complicates treatment by altering metabolism and vasculature.

Purpose of the Study:

  • To review the role of hypoxia in the tumor microenvironment (TME).
  • To examine hypoxia-induced signaling and metabolic pathways in cancer.
  • To discuss hypoxia's impact on angiogenesis, lymphangiogenesis, and therapeutic resistance.

Main Methods:

  • Literature review of studies on hypoxia in cancer.
  • Analysis of molecular mechanisms and signaling pathways.
  • Synthesis of data on metabolic and vascular changes.

Main Results:

  • Hypoxia significantly impacts cancer cell signaling and metabolism.
  • It promotes aberrant tumor vasculature, including angiogenesis and lymphangiogenesis.
  • Hypoxia is a key mediator of resistance to cancer therapies.

Conclusions:

  • Targeting hypoxia-induced pathways is crucial for effective cancer treatment.
  • A deeper understanding of hypoxia's role in the TME is needed.
  • Addressing hypoxia may overcome therapeutic resistance in various cancers.
Keywords:
HIF1⍺Hypoxiaangiogenesiscancerchemoresistanceinflammationlymphangiogenesisradioresistancetumor microenvironment

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