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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Hepatitis E virus and blood transfusion safety.

Hao Bi1, Ru Yang2, Chunchen Wu1

  • 1Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan430070, China.

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|June 30, 2020
PubMed
Summary

Transfusion-transmitted hepatitis E virus (TT-HEV) is a growing concern, especially for immunocompromised patients. Blood screening is increasingly vital to prevent serious liver complications and mortality.

Keywords:
Blood donorsHEVTT-HEVblood safetytransfusion

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Area of Science:

  • Hepatology
  • Transfusion Medicine
  • Public Health Virology

Background:

  • Hepatitis E virus (HEV) is primarily waterborne but transfusion-transmitted HEV (TT-HEV) cases are rising.
  • While often asymptomatic, HEV can cause chronic infection, cirrhosis, and liver failure in immunocompromised individuals, particularly transplant recipients.
  • Increasing global HEV prevalence necessitates addressing TT-HEV risks in blood recipients.

Purpose of the Study:

  • To review evidence and notable cases of TT-HEV infections.
  • To discuss HEV screening protocols for blood donations.
  • To highlight recent trends in implementing broad-based TT-HEV blood screening programs.

Main Methods:

  • Literature review of TT-HEV cases and evidence.
  • Analysis of HEV screening strategies and protocols.
  • Examination of global trends in TT-HEV blood screening implementation.

Main Results:

  • Evidence supports the increasing incidence of TT-HEV.
  • Notable cases illustrate the clinical significance of TT-HEV.
  • Screening protocols and broad-based blood screening programs are evolving.

Conclusions:

  • TT-HEV poses a significant public health risk, particularly for vulnerable patient populations.
  • Effective screening protocols are crucial to mitigate TT-HEV transmission.
  • The implementation of broad-based TT-HEV screening is a growing public health priority worldwide.