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Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

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Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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DNA Bacteriophages01:26

DNA Bacteriophages

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Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
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Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

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In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

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The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
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Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

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Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
962
CRISPR and crRNAs02:53

CRISPR and crRNAs

18.5K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
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Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides

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[Bacteriophage therapy].

Frederik Cold, Nikoline S Olsen, Amaru Indigo Miranda S M Djurhuus

  • 1lhha@plen.ku.dk.

Ugeskrift for Laeger
|June 30, 2020
PubMed
Summary

Bacteriophage therapy shows promise for treating drug-resistant bacterial infections. However, more research is needed to fully understand its effects and establish regulatory approval for clinical use.

Area of Science:

  • Microbiology
  • Virology
  • Infectious Diseases

Background:

  • Bacteriophages are viruses that infect bacteria.
  • Bacteriophage therapy is a potential treatment for multidrug-resistant bacterial infections.
  • Recent studies show promising results for bacteriophage therapy.

Purpose of the Study:

  • To review the potential of bacteriophage therapy for treating resistant bacterial infections.
  • To highlight the need for further research into the mechanisms of bacteriophage therapy.
  • To discuss the regulatory and manufacturing requirements for clinical bacteriophage products.

Main Methods:

  • Literature review of recent studies on bacteriophage therapy.
  • Analysis of the current understanding of bacteriophage treatment effects.

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Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
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Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
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Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
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Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
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  • Examination of regulatory pathways for bacteriophage product approval.

    • Main Results:

    • Bacteriophage therapy presents a viable alternative for combating pan- and multidrug-resistant bacteria.
    • Significant progress has been made in recent years, with promising clinical outcomes reported.
    • The precise mechanisms and full scope of bacteriophage treatment effects require further elucidation.

    Conclusions:

    • Bacteriophage therapy holds considerable potential for treating challenging bacterial infections.
    • Further research is essential to fully understand and optimize bacteriophage treatment efficacy.
    • Development of regulatory frameworks and manufacturing facilities is crucial for widespread clinical adoption in Denmark.