Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Respiratory Syncytial Virus Disease

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Developing Anti-EGFR/Anti-HER2 Bifunctional Antibody for Solid Tumors by Protein Engineering.

Biotechnology and bioengineering·2026

Same author

Relcovaptan: a promising therapeutic agent in traumatic spinal cord injury that acts by modulating newly identified transcriptional regulators of aquaporins compared to tolvaptan.

Turkish journal of medical sciences·2026

Same author

Morpholinoethoxy-Substituted Cationic Metal-Free and Metallo Phthalocyanines: In Vitro Photodynamic Therapy Activities, PDT-Induced ROS Level Measurements, and Cellular Death Mechanism.

ACS bio & med chem Au·2025

Same author

Glycan profiling of multiple sclerosis oligoclonal bands with MALDI-TOF.

Analytical methods : advancing methods and applications·2025

Same author

Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye.

Biochemical genetics·2024

Same author

Antiviral effect of cannabidiol on K18-hACE2 transgenic mice infected with SARS-CoV-2.

Journal of cellular and molecular medicine·2024

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

SARS-CoV-2 neutralizing antibody development strategies.

Bertan Koray BalcioĞlu¹, Melis Denİzcİ ÖncÜ¹, Hasan Ümit ÖztÜrk¹

¹Genetic Engineering and Biotechnology Institute, Marmara Research Center, TÜBİTAK, Kocaeli Turkey.

Turkish Journal of Biology = Turk Biyoloji Dergisi

|June 30, 2020

Summary

Neutralizing antibody therapies targeting the SARS-CoV-2 spike protein offer a promising immediate treatment for COVID-19. This review details development strategies and neutralization assays for these vital antibody treatments.

Keywords:

COVID-19 SARS-CoV-2 animal models display technologies human monoclonal antibody human scFv neutralizing antibodies neutralizing assays

More Related Videos

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Related Experiment Videos

Last Updated: Jun 26, 2026

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Area of Science:

Virology
Immunology
Therapeutics

Background:

The emergence of SARS-CoV-2 in late 2019 led to a rapid global pandemic (COVID-19).
The virus's high transmissibility and significant socioeconomic impact underscore the urgent need for effective treatments.
Currently, no targeted therapies are approved for COVID-19.

Purpose of the Study:

To review current strategies for developing neutralizing antibodies against SARS-CoV-2.
To discuss in vitro and in vivo assays used to evaluate antibody efficacy.

Main Methods:

Focus on neutralizing antibody development targeting the SARS-CoV-2 spike (S) protein.
Examination of assays for assessing antibody neutralization capabilities.

Main Results:

The SARS-CoV-2 S protein is crucial for viral entry via the ACE2 receptor.
Antibody-based treatments are a key focus for immediate therapeutic intervention.
Various development strategies and validation assays are being employed.

Conclusions:

Neutralizing antibodies targeting the SARS-CoV-2 S protein represent a significant therapeutic avenue.
Development and rigorous testing through in vitro and in vivo assays are essential for effective COVID-19 treatments.