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Updated: Dec 17, 2025
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Enoxaparin-Induced Liver Injury
Shehriyar Mehershahi1,2, Nikhitha Mantri2, Aneesh Kumar2
1Department of Gastroenterology, Bronx Care Health System, Bronx, New York, USA.
Case Reports in Gastroenterology
|June 30, 2020
Summary
Enoxaparin, a low-molecular-weight heparin, can cause rare liver injury. This case highlights reversible drug-induced hepatotoxicity, emphasizing prompt diagnosis and discontinuation for patient recovery.
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Low-molecular-weight heparins (LMWHs) like enoxaparin are widely used anticoagulants.
- Hepatocellular injury is a rare but recognized adverse effect of enoxaparin therapy.
Observation:
- A 61-year-old male with pulmonary embolism developed elevated liver enzymes within one week of initiating enoxaparin.
- Clinical presentation suggested drug-induced liver injury.
Findings:
- Enoxaparin-induced hepatotoxicity was diagnosed based on temporal relationship and enzyme profile.
- Discontinuation of enoxaparin led to rapid improvement in liver enzymes.
- Liver enzymes normalized within days of drug cessation, indicating reversibility.
Implications:
- This case underscores the importance of considering enoxaparin as a potential cause of hepatocellular injury.
- Awareness among clinicians is crucial for early detection and management of this rare adverse drug reaction.
- Prompt recognition and withdrawal of the offending agent can lead to favorable outcomes.
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