Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Seizures: Classification01:13

Seizures: Classification

1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

705
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
705
Overview of Synapses01:25

Overview of Synapses

4.4K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
4.4K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

775
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
775
Integration of Synaptic Events01:28

Integration of Synaptic Events

3.3K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reader Response: Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.

Neurology·2025
See all related articles

Related Experiment Video

Updated: Dec 17, 2025

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.3K

Epilepsy and Neuroscience: Evolution and Interaction.

Edward Henry Reynolds1

  • 1Department of Clinical Neurosciences, King's College, London, United Kingdom.

Frontiers in Neuroanatomy
|June 30, 2020
PubMed
Summary

Neuroscience, a multidisciplinary study of the brain, has evolved significantly. The historical understanding of epilepsy, from ancient supernatural beliefs to modern brain-based theories, highlights its role in bridging neurology and psychiatry.

Keywords:
epilepsyhistoryneurologyneurosciencepsychiatry

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.4K

Related Experiment Videos

Last Updated: Dec 17, 2025

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.3K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.4K

Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Neuroscience emerged in the 1950s as a multidisciplinary approach to studying the brain and neuropsychiatric disorders.
  • The collaborative study of neurological and psychiatric disorders has roots dating back to the 17th century and antiquity.
  • Epilepsy's historical understanding evolved from supernatural theories in Babylonian medicine to natural causation in the Greco-Roman period.

Purpose of the Study:

  • To describe the historical evolution of understanding epilepsy.
  • To trace the development of epilepsy from ancient beliefs to modern scientific concepts.
  • To highlight epilepsy's role as a bridge between neurology and psychiatry.

Main Methods:

  • Historical analysis of medical texts and theories related to epilepsy.
  • Tracing the separation of epilepsy from other convulsive diseases.
  • Examining the influence of neuropathology and cortical localization on epilepsy classification.

Main Results:

  • Epilepsy was initially attributed to supernatural causes before being recognized as a brain disorder.
  • The 19th century saw the separation of idiopathic and symptomatic epilepsy and the concept of seizures as electrical discharges.
  • The discovery of the electroencephalogram reinforced the understanding of seizures as electrical brain activity.

Conclusions:

  • Epilepsy has a long history, evolving from ancient beliefs to modern neurological and psychiatric understanding.
  • The study of epilepsy continues to inform our knowledge of brain function and neuropsychiatric disorders.
  • Epilepsy remains a critical area of study, bridging neurology and psychiatry due to its global impact and associated cognitive and psychosocial issues.