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Diabetic Neuropathy: Distribution Pattern Revisited.

Osamu Takahashi1, Ryuji Sakakibara2, Fuyuki Tateno2

  • 1aClinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, Japan.

Case Reports in Neurology
|June 30, 2020
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Summary
This summary is machine-generated.

Multiple mononeuropathy is the most common diabetic neuropathy pattern. This study used nerve conduction studies to link diabetes duration and atherosclerosis risks to specific neuropathy types.

Keywords:
AtherosclerosisDiabetesElderlyMultiple mononeuropathyNeuropathy

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Area of Science:

  • Neurology
  • Diabetology
  • Vascular Medicine

Background:

  • Understanding diabetic neuropathy mechanisms is crucial.
  • Nerve conduction studies (NCS) can differentiate neuropathy patterns.
  • Common patterns include mononeuropathy (unilateral/bilateral), multiple mononeuropathy, and polyneuropathy.

Observation:

  • 323 type 2 diabetic patients underwent NCS.
  • 266 patients had atherosclerosis tests (CAVI, carotid ultrasonography).
  • Neuropathy was present in 235 patients; 88 served as controls.

Findings:

  • Multiple mononeuropathy (26%) was most common, followed by bilateral mononeuropathy (18%), polyneuropathy (16%), and unilateral mononeuropathy (12%).
  • Demyelination and axonal damage were observed.
  • Longer diabetes duration correlated with MNB, MMN, and PN.
  • Higher HbA1C associated with PN.
  • Atherosclerosis risks linked to MNB, MMN, and PN.

Implications:

  • Multiple mononeuropathy is the predominant pattern in diabetes.
  • NCS findings suggest distinct underlying mechanisms for different neuropathy patterns.
  • Identifying specific patterns aids in understanding diabetes complications and managing risks.