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Quantification of γH2AX Foci in Response to Ionising Radiation
Published on: April 7, 2010
Interaction between X-ray and alpha-particle damage in V79 cells
N J McNally1, J de Ronde, M Folkard
1Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Abstract:
V79 cells have been exposed to X-rays or 238Pu alpha-particles or to X-rays following priming alpha-particle doses of 0.5, 2 or 2.5 Gy. The survival curve for exposure to alpha-particles was exponential with a D0 of 0.89 Gy. Following exposure to priming alpha-particle doses the resulting X-ray survival curves had the same slope as the single dose X-ray curve, but a reduced shoulder. For alpha-particle priming doses of 0.5 and 2 Gy this reduction was the same as for the same X-ray doses. 2.5 Gy alpha-particles reduced the subsequent X-ray curve Dq to almost zero. alpha-particles do cause damage capable of interacting with X-ray damage.
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